FDA Approves Xigduo XR (dapagliflozin and metformin hydrochloride) for Type 2 Diabetes {粮食与药物管理局批准第二类型糖尿病的Xigduo XR (dapagliflozin和metformin氯化物)}

Xigduo XR combines two anti-hyperglycemic agents with complementary mechanisms of action, dapagliflozin (trade name in the U.S. Farxiga™), an inhibitor of sodium-glucose cotransporter 2 (SGLT2), and metformin hydrochloride extended-release, a biguanide, in a once-daily oral tablet. SGLT2 inhibitors are a relatively new class of medicines that remove glucose from the body via the kidneys.

Xigduo XR is indicated as an adjunct therapy to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both dapagliflozin and metformin is appropriate.

Xigduo XR is not recommended for patients with type 1 diabetes or diabetic ketoacidosis. The product label for Xigduo XR contains a boxed warning for lactic acidosis, a rare, but serious metabolic complication that can occur due to metformin accumulation during treatment with Xigduo XR

Xigduo XR is not recommended for patients with type 1 diabetes or diabetic ketoacidosis. The product label for Xigduo XR contains a boxed warning for lactic acidosis, a rare, but serious metabolic complication that can occur due to metformin accumulation during treatment with Xigduo XR

Xigduo XR is contraindicated in patients with moderate to severe renal impairment; a history of a serious hypersensitivity to dapagliflozin or to metformin HCl; or with metabolic acidosis, including diabetic ketoacidosis.

Xigduo XR is contraindicated in patients with moderate to severe renal impairment; a history of a serious hypersensitivity to dapagliflozin or to metformin HCl; or with metabolic acidosis, including diabetic ketoacidosis.

Xigduo XR is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both dapagliflozin and metformin is appropriate.

For further details, here is the “Original Article”, courtesy of Drugs.com

My personal experience – Besides medications, one has to exercise and watch the diet to have better diabetic control.